Mycophenolic acid glucuronide → 2-Cyano-6-formyl bicyclo[2.2.1]heptane
반응식
[C]=O.[H][H].[CH3:5][C:6]1[C:11]2CO[C:14](=[O:15])[C:10]=2[C:9](O[C@@H]2O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]2O)=[C:8]([CH2:29]/C=C(/CCC(O)=O)\C)[C:7]=1OC.C(C1CC2CC1CC2C=O)#[N:41]>>[C:29]([CH:8]1[CH2:7][CH:6]2[CH2:5][CH:9]1[CH:10]([CH:14]=[O:15])[CH2:11]2)#[N:41]참가 물질
반응 조건
- 온도
- 100 °C
실험 절차
Next, the inside of the autoclave was sufficiently substituted by nitrogen, and then sufficiently substituted by a gas mixture having a volume ratio of carbon monoxide to hydrogen of 50/50. The same gas was injected until a pressure in the autoclave reached 0.6 MPaG, and the adjustment liquid was heated to 100° C. under stirring, thereby initiating a hydroformylation reaction. Since the pressure in the autoclave decreased with proceeds of the reaction, the gas mixture was continuously supplied so that the pressure was maintained at 0.6 MPaG, the temperature was adjusted so as to be maintained at 100° C., and the hydroformylation reaction was carried out for 6 hours. After the completion of the reaction, the gas mixture in the system was purged using nitrogen, and 276.7 g of a reaction liquid including 2-cyano-5-formyl bicyclo[2.2.1]heptane and 2-cyano-6-formyl bicyclo[2.2.1]heptane was obtained. An analysis showed that the reaction liquid contained 261.8 g (1.76 mol) of the compounds.
후처리
- customa hydroformylation reaction
- customSince the pressure in the autoclave decreased with proceeds of the reaction
- temperatureto be maintained at 100° C.
- customthe hydroformylation reaction
- customAfter the completion of the reaction
- customthe gas mixture in the system was purged
- customnitrogen, and 276.7 g of a reaction liquid
출처 및 근거
- ORD 기록
- ord-17a9a8ea5b6e41babf50cf1a7a493f4a
- 출처 데이터셋
- uspto-grants-2016_01
- 특허 번호
- US09227925B2
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