Hydroquinone → Potassium dobesilate

HRID 587812

반응식

HRID 587812 반응식
[C:1]1([CH:8]=[CH:7][C:5]([OH:6])=[CH:4][CH:3]=1)[OH:2].ClCCl.[S:12](=O)(=[O:15])([OH:14])[OH:13].C(C(CCCC)C([O-])=O)C.[K+:27]>C(OCC)(=O)C>[K+:27].[OH:2][C:1]1[CH:8]=[CH:7][C:5]([OH:6])=[CH:4][C:3]=1[S:12]([O-:15])(=[O:14])=[O:13]

참가 물질

6

반응물 4

HCID 785HydroquinoneHCID 1118Sulfuric AcidHCID 6344DichloromethaneHCID 23669619Potassium 2-ethylhexanoate

생성물 1

HCID 23672329Potassium dobesilate수율 77.9%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매2회

반응 조건

온도
12.5 °C

실험 절차

Hydroquinone (10 g, 0.09 mol) and dichloromethane (30 mL), was taken in a round bottom flask, after cooling the flask to about 10-15° C., sulfuric acid (36 N, 8.9 g) was added dropwise at the same temperature and stirring continued further for about 10-15 min. Temperature was slowly raised to 30-40° C. then stirred for 1-2 h. The reaction mass was then cooled to 25-35° C. and ethyl acetate (100 mL) added to dissolve the solid formed. A solution of potassium 2-ethylhexanoate (18.2 g, 0.099 mol) in ethyl acetate (100 mL) was added slowly. The reaction was further stirred for an hour. The precipitated crude solid was filtered, washed with ethyl acetate to give 16 g of 2,5-dihydroxybenzenesulfonic acid potassium salt.

후처리

  1. temperatureTemperature was slowly raised to 30-40° C.
  2. stirringthen stirred for 1-2 h
  3. temperatureThe reaction mass was then cooled to 25-35° C.
  4. dissolutionto dissolve the solid
  5. customformed
  6. stirringThe reaction was further stirred for an hour
  7. customThe precipitated crude solid
  8. filtrationwas filtered
  9. washwashed with ethyl acetate

출처 및 근거

ORD 기록
ord-06ae9ecef4334649a355952e273299a2
출처 데이터셋
uspto-grants-2016_01
특허 번호
US09227928B2

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