Methanol → 3-Bromotricyclo[3.3.1.13,7]decane-1-methanol

HRID 588659

반응식

HRID 588659 반응식
O1CCCC1.B.CO.[Br:9][C:10]12[CH2:19][CH:14]3[CH2:15][CH:16]([CH2:18][C:12]([C:20](O)=[O:21])([CH2:13]3)[CH2:11]1)[CH2:17]2>O1CCCC1>[Br:9][C:10]12[CH2:19][CH:14]3[CH2:15][CH:16]([CH2:18][C:12]([CH2:20][OH:21])([CH2:13]3)[CH2:11]1)[CH2:17]2

참가 물질

5

반응물 3

HCID 887MethanolHCID 308183-Bromoadamantane-1-carboxylic acidHCID 2723981Borane;tetrahydrofuran

생성물 1

HCID 28029653-Bromotricyclo[3.3.1.13,7]decane-1-methanol

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

In a 250 ml round-bottomed flask, 3-bromoadamantane-1-carboxylic acid (7.89 g) was dissolved in tetrahydrofuran (30 mL). Borane tetrahydrofuran complex (1M in hexane, 60 mL) was added slowly. The mixture was stirred at room temperature overnight. Methanol (20 mL) was added to the solution slowly. After removal of the solvents, methanol (5 mL) was added to the oily residue. Removal of the solvent provided the title compound.

후처리

  1. customAfter removal of the solvents, methanol (5 mL)
  2. additionwas added to the oily residue
  3. customRemoval of the solvent

출처 및 근거

ORD 기록
ord-e6c059fa17084a0aa24924dd56f1effb
출처 데이터셋
uspto-grants-2016_01
특허 번호
US09227963B2

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