Methanol → Methyl tricyclo[3.3.1.13,7]decane-2-carboxylate

HRID 588679

반응식

HRID 588679 반응식
[CH:1]12[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH:2]1[C:11]([OH:13])=[O:12])[CH2:8]2.CO.[CH3:16][Si](C=[N+]=[N-])(C)C>C(OCC)(=O)C>[CH:3]12[CH2:9][CH:7]3[CH2:6][CH:5]([CH2:10][CH:1]([CH2:8]3)[CH:2]1[C:11]([O:13][CH3:16])=[O:12])[CH2:4]2

참가 물질

5

반응물 3

HCID 887MethanolHCID 167693TrimethylsilyldiazomethaneHCID 3038022-Adamantanecarboxylic acid

생성물 1

HCID 12600018Methyl tricyclo[3.3.1.13,7]decane-2-carboxylate

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

To a solution of adamantane-2-carboxylic acid 1 (0.486 g, 2.70 mmol) in ethyl acetate (10 mL)/methanol (5 mL) was dropwise added (trimethylsilyl)diazomethane (1.348 ml, 2.70 mmol) and the mixture was stirred at room temperature for 14 hours. The reaction mixture was concentrated and purified by flash chromotography (silica 40 g, 0%-30% ethyl acetate/hexanes).

후처리

  1. concentrationThe reaction mixture was concentrated
  2. custompurified by flash chromotography (silica 40 g, 0%-30% ethyl acetate/hexanes)

출처 및 근거

ORD 기록
ord-a6b5f921f65d421298968a9096472616
출처 데이터셋
uspto-grants-2016_01
특허 번호
US09227963B2

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