Sodium Iodide → HCID 90455791, 화합물

HRID 588910노트

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HRID 588910 반응식
[Cl:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[CH:5]=[CH:4][C:3]=1[CH:10]=[CH2:11].[Si]([C:16]([F:19])(F)[F:17])(C)(C)C.[Na+].[I-]>C1COCC1.CCCCCC>[Cl:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[CH:5]=[CH:4][C:3]=1[CH:10]1[CH2:11][C:16]1([F:19])[F:17]

참가 물질

6

반응물 3

HCID 5238Sodium IodideHCID 552549(Trifluoromethyl)trimethylsilaneHCID 904560122-Chloro-4-methoxy-1-vinylbenzene

생성물 1

HCID 90455791HCID 90455791, 화합물

시약·촉매·용매 2

HCID 8028Tetrahydrofuran용매HCID 8058Hexane용매2회

반응 조건

온도
80 °C

실험 절차

The solution of 2-chloro-4-methoxy-1-vinylbenzene (290 mg, 1.72 mmol) in dry THF (4 mL) was degassed, and then TMS-CF3 and NaI were added. The mixture was stirred at 80° C. overnight. TLC (100% Hexane) showed the reaction as complete. The mixture was diluted with hexane (20 mL). The inorganic salt was removed by filtration. The filtrate was concentrate in vacuo. The residue was purified via Isolera One (Hexane=100%).

후처리

  1. customthe reaction as complete
  2. customThe inorganic salt was removed by filtration
  3. concentrationThe filtrate was concentrate in vacuo
  4. customThe residue was purified via Isolera One (Hexane=100%)

출처 및 근거

ORD 기록
ord-7a05b2e6b7874c4f9c5e1c48ee4d68dc
출처 데이터셋
uspto-grants-2016_01
특허 번호
US09227978B2

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