Benzyl 2-(4-hydroxypiperidin-1-yl)acetate → 2-(4-Hydroxypiperidin-1-yl)acetic acid

HRID 58894노트

반응식

HRID 58894 반응식
[OH:1][CH:2]1[CH2:7][CH2:6][N:5]([CH2:8][C:9]([O:11]CC2C=CC=CC=2)=[O:10])[CH2:4][CH2:3]1>CO.[Pd]>[OH:1][CH:2]1[CH2:3][CH2:4][N:5]([CH2:8][C:9]([OH:11])=[O:10])[CH2:6][CH2:7]1

참가 물질

4

반응물 1

HCID 21805034Benzyl 2-(4-hydroxypiperidin-1-yl)acetate

생성물 1

HCID 112059272-(4-Hydroxypiperidin-1-yl)acetic acid수율 94.2%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A mixture of benzyl 2-(4-hydroxypiperidin-1-yl)acetate (1.0 g, 4.0 mmol) and Pd/C (0.1 g) in methanol (20 mL) was hydrogenated for 1 h at ambient temperature. The Pd/C was filtered off and the filtrate was concentrated to dryness to afford 2-(4-hydroxypiperidin-1-yl)acetic acid (0.6 g, 94% yield).

후처리

  1. filtrationThe Pd/C was filtered off
  2. concentrationthe filtrate was concentrated to dryness

출처 및 근거

ORD 기록
ord-0ee9a04ec4db4b5b8a636c014129ccd8
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09434761B2

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