Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzyl carbamate → Ethyl 2-(benzyloxycarbonylamino)-3,3,3-trifluoro-2-hydroxypropanoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzyl carbamate | HCID 12136 | — |
| 반응물 | Ethyl 3,3,3-trifluoro-2-oxopropanoate | HCID 2737239 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | Ethyl 2-(benzyloxycarbonylamino)-3,3,3-trifluoro-2-hydroxypropanoate | HCID 14377410 | 87% |
반응 단계
To a solution of ethyl 3,3,3-trifluoro-2-oxopropanoate (30 g, 176 mmol) in dichloromethane (1 L) was added benzyl carbamate (26.6 g). The reaction mixture was stirred at ambient temperature for 24 h and the resulting precipitate was collected by filtration and dried under vacuum to afford ethyl 2-(benzyloxycarbonylamino)-3,3,3-trifluoro-2-hydroxypropanoate (49.0 g, 87% yield), which was used directly without further purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09434761B2 |
| 출처 데이터셋 | uspto-grants-2016_09 |
| ORD ID | ord-0013123ac2054632854381318601ebc4 |
| 출처 메모 | uspto-grants-2016_09 |