Ammonium Hydroxide → 5-Chloropyrazolo[1,5-a]pyrimidin-7-amine

HRID 589153

반응식

HRID 589153 반응식
[Cl:1][C:2]1[CH:7]=[C:6](Cl)[N:5]2[N:9]=[CH:10][CH:11]=[C:4]2[N:3]=1.[NH4+:12].[OH-]>>[Cl:1][C:2]1[CH:7]=[C:6]([NH2:12])[N:5]2[N:9]=[CH:10][CH:11]=[C:4]2[N:3]=1

참가 물질

3

반응물 2

HCID 14923Ammonium HydroxideHCID 110741545,7-Dichloropyrazolo[1,5-a]pyrimidine

생성물 1

HCID 231319095-Chloropyrazolo[1,5-a]pyrimidin-7-amine

반응 조건

온도
85 °C

실험 절차

To 5,7-dichloropyrazolo[1,5-a]pyrimidine (7.6 g, 40.4 mmol) in a sealed vessel was added NH4OH (100 mL). The vessel was then sealed and heated at 85° C. for 2.5 hours, at which time the consistency of the white solid had changed (from foamy white solid to free-flowing white solid). The vessel was removed from the heat source and allowed to cool to room temperature overnight. On cooling, the contents of the vessel were collected and dried by vacuum filtration giving 5-chloropyrazolo[1,5-a]pyrimidin-7-amine as a yellow-tinged white solid (6.8 g).

후처리

  1. customThe vessel was then sealed
  2. customThe vessel was removed from the heat source
  3. temperatureto cool to room temperature overnight
  4. temperatureOn cooling
  5. customthe contents of the vessel were collected
  6. customdried by vacuum filtration

출처 및 근거

ORD 기록
ord-62ddcfe51f8a41c18e1c5170c8284292
출처 데이터셋
uspto-grants-2016_01
특허 번호
US09227971B2

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