Cyclopropylamine → 5-bromo-N-cyclopropylpyridin-2-amine
반응식
[Br:1][C:2]1[CH:3]=[CH:4][C:5](F)=[N:6][CH:7]=1.[CH:9]1([NH2:12])[CH2:11][CH2:10]1>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([NH:12][CH:9]2[CH2:11][CH2:10]2)=[N:6][CH:7]=1참가 물질
3
반응 조건
- 온도
- 80 °C
실험 절차
To a sealed tube was added 5-bromo-2-fluoropyridine (1.25 g, 7.10 mmol) and cyclopropylamine (5.0 mL, 72 mmol). Upon heating at 80° C. for 48 hours the reaction was complete. The contents of the tube were transferred to a round bottom flask and concentrated in vacuo. The remaining residue was dissolved in dichloromethane and washed twice with saturated sodium bicarbonate and twice with brine. The organics were dried over sodium sulfate, filtered and concentrated in vacuo to afford the title compound (1.13 g, 75%) as a tan solid.
후처리
- customThe contents of the tube were transferred to a round bottom flask
- concentrationconcentrated in vacuo
- dissolutionThe remaining residue was dissolved in dichloromethane
- washwashed twice with saturated sodium bicarbonate and twice with brine
- dry with materialThe organics were dried over sodium sulfate
- filtrationfiltered
- concentrationconcentrated in vacuo
출처 및 근거
- ORD 기록
- ord-2d2e22ead0cd40ed813cf1029e9ffbeb
- 출처 데이터셋
- uspto-grants-2016_01
- 특허 번호
- US09227971B2
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