Dimethylamine → 1-(2-Dimethylaminoacetyl)-7-nitro-1,2,3,4-tetrahydroquinoline

HRID 589311노트

반응식

HRID 589311 반응식
Cl[CH2:2][C:3]([N:5]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([N+:15]([O-:17])=[O:16])[CH:13]=2)[CH2:8][CH2:7][CH2:6]1)=[O:4].[CH3:18][NH:19][CH3:20]>C1COCC1>[CH3:18][N:19]([CH3:20])[CH2:2][C:3]([N:5]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([N+:15]([O-:17])=[O:16])[CH:13]=2)[CH2:8][CH2:7][CH2:6]1)=[O:4]

참가 물질

4

반응물 2

HCID 674DimethylamineHCID 125783601-(Chloroacetyl)-7-nitro-1,2,3,4-tetrahydroquinoline

생성물 1

HCID 569786941-(2-Dimethylaminoacetyl)-7-nitro-1,2,3,4-tetrahydroquinoline

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

2-chloro-1-(7-nitro-3,4-dihydroquinolin-1(2H)-yl)ethanone (1 g, 3.9 mmol) was dissolved in 10 ml of dry THF and 7.8 ml of a 1M solution of dimethylamine in THF (7.8 mmol) were added. This reaction mixture was stirred at ambient temperature for 24 h. The solvent was removed under reduced pressure and the residue was crystallized from diethyl ether to give the expected compound 2-(dimethylamino)-1-(7-nitro-3,4-dihydroquinolin-1(2H)-yl)ethanone in the form of a brown solid (Mp 130-132° C.).

후처리

  1. customThe solvent was removed under reduced pressure
  2. customthe residue was crystallized from diethyl ether

출처 및 근거

ORD 기록
ord-f1382a3da34e4d9f816fb1f162021e0e
출처 데이터셋
uspto-grants-2016_01
특허 번호
US09233060B2

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