ethyl 2-[2-methyl-3-(4-nitrobenzyl)-1H-indol-1-yl]acetate → HCID 89590249, 화합물

HRID 589338노트

반응식

HRID 589338 반응식
[CH3:1][C:2]1[N:3]([CH2:21][C:22]([O:24][CH2:25][CH3:26])=[O:23])[C:4]2[C:9]([C:10]=1[CH2:11][C:12]1[CH:17]=[CH:16][C:15]([N+:18]([O-])=O)=[CH:14][CH:13]=1)=[CH:8][CH:7]=[CH:6][CH:5]=2>CO.[Pd]>[NH2:18][C:15]1[CH:14]=[CH:13][C:12]([CH2:11][C:10]2[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[N:3]([CH2:21][C:22]([O:24][CH2:25][CH3:26])=[O:23])[C:2]=2[CH3:1])=[CH:17][CH:16]=1

참가 물질

4

반응물 1

HCID 89590291ethyl 2-[2-methyl-3-(4-nitrobenzyl)-1H-indol-1-yl]acetate

생성물 1

HCID 89590249HCID 89590249, 화합물수율 92.3%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

Into a dry reaction vessel, ethyl 2-[2-methyl-3-(4-nitrobenzyl)-1H-indol-1-yl]acetate (2.7 g, 7.66 mmol) was added, and dissolved in 30 mL methanol. 10% Pd/C 300 mg was added, purged with hydrogen, and reacted overnight. After completion of the reaction, it was filtered, and the filter cake was washed with methanol. The filtrate was rotate evaporated to dryness to obtain a white solid 2.28 g, at a yield of 92.3%.

후처리

  1. additionwas added
  2. custompurged with hydrogen
  3. customreacted overnight
  4. customAfter completion of the reaction, it
  5. filtrationwas filtered
  6. washthe filter cake was washed with methanol
  7. customThe filtrate was rotate evaporated to dryness

출처 및 근거

ORD 기록
ord-d107c81be49a4042b277ff6bf056454e
출처 데이터셋
uspto-grants-2016_01
특허 번호
US09233098B2

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