ethyl 2-[3-(4-nitrobenzyl)-1H-indazol-1-yl]acetate → ethyl 2-[3-(4-aminobenzyl)-1H-indazol-1-yl]acetate

HRID 589348노트

반응식

HRID 589348 반응식
[N+:1]([C:4]1[CH:25]=[CH:24][C:7]([CH2:8][C:9]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[N:11]([CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20])[N:10]=2)=[CH:6][CH:5]=1)([O-])=O>CO.[Pd]>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([CH2:8][C:9]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[N:11]([CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20])[N:10]=2)=[CH:24][CH:25]=1

참가 물질

4

반응물 1

HCID 89590255ethyl 2-[3-(4-nitrobenzyl)-1H-indazol-1-yl]acetate

생성물 1

HCID 89590284ethyl 2-[3-(4-aminobenzyl)-1H-indazol-1-yl]acetate수율 53.3%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

1.3 g (3.83 mmol) ethyl 2-[3-(4-nitrobenzyl)-1H-indazol-1-yl]acetate was dissolved in 40 mL methanol. 200 mg palladium on carbon was added, and reacted under an atmosphere of H2 at room temperature overnight. It was filtered to remove solid, rotate evaporated to dryness to remove the solvent, and separated by a preparative chromatography to obtain a white solid 630 mg, at a yield of 53.3%.

후처리

  1. customreacted under an atmosphere of H2 at room temperature overnight
  2. filtrationIt was filtered
  3. customto remove solid
  4. customrotate evaporated to dryness
  5. customto remove the solvent
  6. customseparated by a preparative chromatography

출처 및 근거

ORD 기록
ord-3980d90367aa4ddeb7b4f496eaec4e9a
출처 데이터셋
uspto-grants-2016_01
특허 번호
US09233098B2

반응 노트

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