Ethanol → HCID 178470794, 화합물

반응식

[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([CH2:10][C:11]([OH:13])=[O:12])=[N:2]1.[CH2:14](O)[CH3:15]>>[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])=[N:2]1

참가 물질

반응물 2

HCID 702Ethanol

HCID 178525248HCID 178525248, 화합물

생성물 1

HCID 178470794HCID 178470794, 화합물수율 87.8%

실험 절차

2-(1H-indazol-3-yl)acetic acid (3.9 g, 22.1 mmol) was dissolved in anhydrous ethanol (100 mL) concentrated sulfuric acid (5 mL), and heated under reflux for 16 hours. It was concentrated under reduce pressure to remove most of ethanol, then water (30 mL) was added, and extracted with ethyl acetate. The organic phase was dried over anhydrous sodium sulfate, concentrated to obtain the product 3.96 g, at a yield of 87.8%.

후처리

temperatureheated
temperatureunder reflux for 16 hours
concentrationIt was concentrated
customto remove most of ethanol
additionwater (30 mL) was added
extractionextracted with ethyl acetate
dry with materialThe organic phase was dried over anhydrous sodium sulfate
concentrationconcentrated

출처 및 근거

ORD 기록: ord-dd0e378a617d43fc844ce584449dd079
출처 데이터셋: uspto-grants-2016_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09233098B2

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