Ethyl Acetate → ethyl 2-[1-(4-aminobenzyl)-1H-indazol-3-yl]acetate

HRID 589368노트

반응식

HRID 589368 반응식
[N+:1]([C:4]1[CH:25]=[CH:24][C:7]([CH2:8][N:9]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[C:11]([CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20])=[N:10]2)=[CH:6][CH:5]=1)([O-])=O.C(OCC)(=O)C>CO.[Pd]>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([CH2:8][N:9]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[C:11]([CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20])=[N:10]2)=[CH:24][CH:25]=1

참가 물질

5

반응물 2

HCID 8857Ethyl AcetateHCID 89590252ethyl 2-[1-(4-nitrobenzyl)-1H-indazol-3-yl]acetate

생성물 1

HCID 89590263ethyl 2-[1-(4-aminobenzyl)-1H-indazol-3-yl]acetate

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

Ethyl 2-[1-(4-nitrobenzyl)-1H-indazol-3-yl]acetate (225 mg, 0.663 mmol) was dissolved in methanol (20 mL). 10% Pd/C(18 mg) was added, and reacted under hydrogen atmosphere for half an hour. TLC (petroleum ether:ethyl acetate=2:1) indicated that starting material disappeared. It was filtered to remove solid, rotate evaporated to dryness to remove the solvent, and the resulting solid was used for the next step directly.

후처리

  1. customreacted under hydrogen atmosphere for half an hour
  2. filtrationIt was filtered
  3. customto remove solid
  4. customrotate evaporated to dryness
  5. customto remove the solvent

출처 및 근거

ORD 기록
ord-5880217a35b947ceb26a45746014af6d
출처 데이터셋
uspto-grants-2016_01
특허 번호
US09233098B2

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