Ethyl Acetate → ethyl 2-[1-(4-aminobenzyl)-1H-indazol-3-yl]acetate

HRID 589384노트

반응식

HRID 589384 반응식
[N+:1]([C:4]1[CH:25]=[CH:24][C:7]([CH2:8][N:9]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[C:11]([CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20])=[N:10]2)=[CH:6][CH:5]=1)([O-])=O.C(OCC)(=O)C>CO.[Pd]>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([CH2:8][N:9]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[C:11]([CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20])=[N:10]2)=[CH:24][CH:25]=1

참가 물질

5

반응물 2

HCID 8857Ethyl AcetateHCID 89590252ethyl 2-[1-(4-nitrobenzyl)-1H-indazol-3-yl]acetate

생성물 1

HCID 89590263ethyl 2-[1-(4-aminobenzyl)-1H-indazol-3-yl]acetate

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

Ethyl 2-[1-(4-nitrobenzyl)-1H-indazol-3-yl]acetate (340 mg, 1.0 mmol) was dissolved in methanol (20 mL). 10% Pd/C(20 mg) was added, and reacted under hydrogen atmosphere for half an hour. TLC (petroleum ether:ethyl acetate=2:1) indicated that starting material disappeared. It was filtered to remove solid, rotate evaporated to dryness to remove the solvent, and the resulting solid was used for the next step directly.

후처리

  1. customreacted under hydrogen atmosphere for half an hour
  2. filtrationIt was filtered
  3. customto remove solid
  4. customrotate evaporated to dryness
  5. customto remove the solvent

출처 및 근거

ORD 기록
ord-5c52bbc6a9eb4cffb75ed22df009f2e4
출처 데이터셋
uspto-grants-2016_01
특허 번호
US09233098B2

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