Oxalyl chloride → 6-Fluoro-2-naphthoyl chloride

HRID 589385

반응식

HRID 589385 반응식
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([C:12]([OH:14])=O)[CH:6]=[CH:5]2.C(Cl)(=O)C([Cl:18])=O>ClCCl.CN(C)C=O>[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([C:12]([Cl:18])=[O:14])[CH:6]=[CH:5]2

참가 물질

5

반응물 2

HCID 65578Oxalyl chlorideHCID 27827886-Fluoro-2-naphthoic acid

생성물 1

HCID 866748346-Fluoro-2-naphthoyl chloride

시약·촉매·용매 2

HCID 6228Dimethylformamide용매HCID 6344Dichloromethane용매

실험 절차

6-Fluoro-2-naphthoic acid (228 mg, 1.2 mmol) was dissolved in dichloromethane (15 mL) and N,N-dimethylformamide (0.1 mL), and in an ice bath oxalic chloride (228 mg, 1.8 mmol) was added dropwise slowly. Upon completion of the dropwise addition, it was moved to react at room temperature for 3 hours, and concentrated under reduce pressure to obtain a white solid, i.e. 6-fluoro-2-naphthoyl chloride.

후처리

  1. additionUpon completion of the dropwise addition, it
  2. customto react at room temperature for 3 hours
  3. concentrationconcentrated

출처 및 근거

ORD 기록
ord-a0b272b1e5734728a4e677fa84822678
출처 데이터셋
uspto-grants-2016_01
특허 번호
US09233098B2

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