Pyridine → 2,3,4-Trichloro-N-[3-(1H-tetrazol-5-yl)phenyl]benzenesulfonamide

HRID 589680노트

반응식

HRID 589680 반응식
[Cl:1][C:2]1[C:7]([Cl:8])=[C:6]([Cl:9])[CH:5]=[CH:4][C:3]=1[S:10](Cl)(=[O:12])=[O:11].[NH2:14][C:15]1[CH:16]=[C:17]([C:21]2[NH:25][N:24]=[N:23][N:22]=2)[CH:18]=[CH:19][CH:20]=1.N1C=CC=CC=1>C(Cl)Cl>[Cl:1][C:2]1[C:7]([Cl:8])=[C:6]([Cl:9])[CH:5]=[CH:4][C:3]=1[S:10]([NH:14][C:15]1[CH:20]=[CH:19][CH:18]=[C:17]([C:21]2[NH:25][N:24]=[N:23][N:22]=2)[CH:16]=1)(=[O:12])=[O:11]

참가 물질

5

반응물 3

HCID 1049PyridineHCID 369042,3,4-Trichlorobenzenesulfonyl chlorideHCID 178507542HCID 178507542, 화합물

생성물 1

HCID 1785275052,3,4-Trichloro-N-[3-(1H-tetrazol-5-yl)phenyl]benzenesulfonamide수율 65%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A solution of 2,3,4-trichlorobenzenesulfonyl chloride (15 mg, 0.055 mmol), 5-(3-aminophenyl)tetrazole (8 mg, 0.05 mmol) and dry pyridine (12 μL) in CH2Cl2 (200 μL) was stirred at room temperature over night. The solvent was evaporated and the crude product was purified by preparative HPLC (ACE C8, 5 μm 21×50 mm, flow 25 ml/min, 50 mM NH4OAc in water/CH3CN) to give 13 mg (65%) of the title compound. MS (ESI+) calcd for C13H8Cl3N5O2S 402.946428, found 402.946188.

후처리

  1. customThe solvent was evaporated
  2. customthe crude product was purified by preparative HPLC (ACE C8, 5 μm 21×50 mm, flow 25 ml/min, 50 mM NH4OAc in water/CH3CN)

출처 및 근거

ORD 기록
ord-6cf7232f46054717b933c3d50abe3712
출처 데이터셋
uspto-grants-2016_01
특허 번호
US09233946B2

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