Sodium Carbonate → Ticagrelor

HRID 589829노트

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HRID 589829 반응식
[CH3:1][CH2:2][CH2:3][S:4][C:5]1[N:6]=[C:7]([NH:25][C@H:26]2[C@H:28]([C:29]3[CH:30]=[CH:31][C:32]([F:36])=[C:33]([F:35])[CH:34]=3)[CH2:27]2)[C:8]2[N:13]=[N:12][N:11]([C@H:14]3[C@H:18]([OH:19])[C@H:17]([OH:20])[C@@H:16]([O:21][CH2:22][CH2:23][OH:24])[CH2:15]3)[C:9]=2[N:10]=1.C([O-])(=O)CC([O-])=O.C(=O)([O-])[O-].[Na+].[Na+]>C(OCC)(=O)C>[CH3:1][CH2:2][CH2:3][S:4][C:5]1[N:6]=[C:7]([NH:25][C@H:26]2[C@H:28]([C:29]3[CH:30]=[CH:31][C:32]([F:36])=[C:33]([F:35])[CH:34]=3)[CH2:27]2)[C:8]2[N:13]=[N:12][N:11]([C@H:14]3[C@H:18]([OH:19])[C@H:17]([OH:20])[C@@H:16]([O:21][CH2:22][CH2:23][OH:24])[CH2:15]3)[C:9]=2[N:10]=1

참가 물질

4

반응물 2

HCID 10340Sodium CarbonateHCID 131734470Ticagrelor malonate

생성물 1

HCID 9871419Ticagrelor

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

Ticagrelor malonate (0.5 g) and ethyl acetate (10 mL) were charged into round bottom flask. To the mixture 10% aqueous sodium carbonate solution (50 mL) was added and mixture was stirred for 15 minutes. The layers were separated and organic layer was subjected to distillation under vacuum to afford the title compound.

후처리

  1. customThe layers were separated
  2. distillationorganic layer was subjected to distillation under vacuum

출처 및 근거

ORD 기록
ord-31246c698edb43a1919f28f4968f9693
출처 데이터셋
uspto-grants-2016_01
특허 번호
US09233966B2

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