Sulfuryl chloride → N-cyclobutylsulfamoyl chloride

HRID 589953노트

반응식

HRID 589953 반응식
[S:1]([Cl:5])(Cl)(=[O:3])=[O:2].Cl.[CH:7]1([NH2:11])[CH2:10][CH2:9][CH2:8]1>CC#N>[CH:7]1([NH:11][S:1]([Cl:5])(=[O:3])=[O:2])[CH2:10][CH2:9][CH2:8]1

참가 물질

4

반응물 2

HCID 24648Sulfuryl chlorideHCID 12618374Cyclobutanamine, hydrochloride (1:1)

생성물 1

HCID 22326606N-cyclobutylsulfamoyl chloride

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

Sulfuryl chloride (104 mmol) was dissolved in dry CH3CN (25 mL), added cyclobutylamine hydrochloride (31 mmol) and stirred at reflux for 16 h. The obtained reaction mixture was cooled to rt and concentrated in vacuo. The obtained residue was trituated with Et2O (2×25 mL). The combined Et2O-phases were concentrated in vacuo affording the title compound as oil.

후처리

  1. temperatureat reflux for 16 h
  2. customThe obtained reaction mixture
  3. concentrationconcentrated in vacuo
  4. concentrationThe combined Et2O-phases were concentrated in vacuo

출처 및 근거

ORD 기록
ord-62c3fc2be6e84f288f350fcd29fe402c
출처 데이터셋
uspto-grants-2016_01
특허 번호
US09233964B2

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