Nitric Acid → Methyl 2,6-Difluoro-3-nitrobenzoate
반응식
[N+:1]([O-:4])(O)=[O:2].[F:5][C:6]1[CH:15]=[CH:14][CH:13]=[C:12]([F:16])[C:7]=1[C:8]([O:10][CH3:11])=[O:9]>S(=O)(=O)(O)O>[F:5][C:6]1[C:15]([N+:1]([O-:4])=[O:2])=[CH:14][CH:13]=[C:12]([F:16])[C:7]=1[C:8]([O:10][CH3:11])=[O:9]참가 물질
4
반응 조건
- 온도
- 0 °C
실험 절차
Fuming nitric acid (11 g, 174 mmol) was added to a solution of methyl 2,6-difluorobenzoate (25 g, 145 mmol) in concentrated sulfuric acid (50 mL) at 0° C., and the reaction was stirred for 30 min at 0° C. The reaction mixture was poured over ice-water. The precipitate was filtered off by suction to give the desired product of Step B (25.1 g, 80.6%). 1H NMR (400 MHz, CDCl3) δ ppm 8.13-8.20 (m, 1H), 7.02-7.10 (m, 1H), 3.93 (s, 3H).
후처리
- filtrationThe precipitate was filtered off by suction
출처 및 근거
- ORD 기록
- ord-1eb4237a28134589a57c4703cda7972c
- 출처 데이터셋
- uspto-grants-2016_01
- 특허 번호
- US09233956B2
반응 노트
불러오는 중…