8-(Methyloxy)-2-{[(1S)-1-methylpropyl]oxy}-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine → HCID 178456042, 화합물

HRID 590454노트

반응식

HRID 590454 반응식
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[CH3:8][C@H:9]([O:13][C:14]1[N:22]=[C:21]2[C:17]([N:18]=[C:19]([O:23][CH3:24])[NH:20]2)=[C:16]([NH2:25])[N:15]=1)[CH2:10][CH2:11]C.COC1N(C2CCCCO2)C2C(N=1)=C(N)N=C(O[C@@H](C)CC)N=2>>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[CH3:24][O:23][C:19]1[N:20]=[C:21]2[C:17]([N:18]=1)=[C:16]([NH2:25])[NH:15][C:14]([O:13][C@@H:9]([CH3:8])[CH2:10][CH3:11])=[N:22]2

참가 물질

3

반응물 2

HCID 592526388-(Methyloxy)-2-{[(1S)-1-methylpropyl]oxy}-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amineHCID 178448286HCID 178448286, 화합물

생성물 1

HCID 178456042HCID 178456042, 화합물

실험 절차

Prepared similarly to Intermediate 12 from 8-(methyloxy)-2-{[(1S)-1-methylpropyl]oxy}-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine.

출처 및 근거

ORD 기록
ord-12ccb022926f47b6abcabcf41de21b83
출처 데이터셋
uspto-grants-2016_01
특허 번호
US09233962B2

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