참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Methylglyoxal | HCID 880 | — |
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | Glycinehydroxamic acid | HCID 94811 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | HCID 178430963 | HCID 178430963 | 57.7% |
반응 단계
100 mmol (9 g) glycine hydroxamic acid were cooled to −25° C. in 200 ml water and methanol each, 100 mmol (15.4 ml 40% solution) methylglyoxal were added dropwise and subsequently the pH was adjusted to approximately pH 11 with 10 ml 30% NaOH. Heating up to 5° C. was carried out in 2 h and concentrated under vacuum to half of the solvent volume. A pH 3 was adjusted with 20% HCl, precipitated solid was filtered off and dried. 7.28 g (52% yield) of the title compound were obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US09439910B2 |
|---|
| 출처 데이터셋 | uspto-grants-2016_09 |
|---|
| ORD ID | ord-4d7c9ee2a2db4964a663905b500c8598 |
|---|
| 출처 메모 | uspto-grants-2016_09 |
|---|
