반응식
[CH3:1][CH:2]([C:5]([OH:7])=[O:6])[CH2:3][NH2:4].O=S(Cl)[Cl:10].[CH3:12]O>>[ClH:10].[NH2:4][CH2:3][CH:2]([CH3:1])[C:5]([O:7][CH3:12])=[O:6]참가 물질
4
실험 절차
To the solution of DL-3-aminoisobutyric acid (CAS number: 144-90-1, Aldrich) (2.7 g, 26.4 mmol) in MeOH (50 mL) was added SOCl2 (6.17 g, 52.8 mmol) dropwise at 0° C. under N2 atmosphere. The reaction was refluxed for 18 hours. The solvent was removed in vacuo to give crude Compound W which was used directly in the next step.
후처리
- temperatureThe reaction was refluxed for 18 hours
- customThe solvent was removed in vacuo
출처 및 근거
- ORD 기록
- ord-3bdec371188e4bf5bf7e54409d90ba2b
- 출처 데이터셋
- uspto-grants-2016_01
- 특허 번호
- US09233978B2
연결된 노트
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