HCID 118271795, 화합물 → (αS)-α-(1-Methoxy-1-methylethyl)benzenemethanamine

HRID 590792노트

반응식

HRID 590792 반응식
[CH3:1][O:2][C:3]([CH3:31])([CH3:30])[C@H:4]([C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)[N:5](CC1C=CC(OC)=CC=1)CC1C=CC(OC)=CC=1>CO.[Pd]>[CH3:1][O:2][C:3]([CH3:31])([CH3:30])[C@H:4]([C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)[NH2:5]

참가 물질

4

반응물 1

HCID 118271795HCID 118271795, 화합물

생성물 1

HCID 57791001(αS)-α-(1-Methoxy-1-methylethyl)benzenemethanamine

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A solution of (S)-2-methoxy-N,N-bis(4-methoxybenzyl)-2-methyl-1-phenylpropan-1-amine (0.7 g, 1.67 mmol) in anhydrous MeOH was added Pd on C (0.1 g) and the contents were stirred at ambient temperature in H2 atmosphere. After 14 h, the reaction mixture was filtered through a pad of celite and the volatiles were removed under reduced pressure. The residue thus obtained was further purified by preparative HPLC to afford the title compound. H1NMR (ppm, 400 MHz, CDCl3) δ 7.45-7.44 (m, 2H), 7.35-7.33 (m, 3H), 4.1 (s, 1H), 3.32 (s, 3H), 1.2 (s, 3H), 1.12 (s, 3H).

후처리

  1. filtrationthe reaction mixture was filtered through a pad of celite
  2. customthe volatiles were removed under reduced pressure
  3. customThe residue thus obtained
  4. customwas further purified by preparative HPLC

출처 및 근거

ORD 기록
ord-010482e02de149218431703cedb3e785
출처 데이터셋
uspto-grants-2016_01
특허 번호
US09233979B2

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