1,5-Dihydroxynaphthalene → 1,5-Bis-(2-ethylhexyloxy)naphthalene

HRID 590901

반응식

HRID 590901 반응식
O[C:2]1[C:11]2[C:6](=[C:7]([OH:12])[CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][CH:3]=1.[C:13](=[O:16])([O-])[O-].[K+].[K+].[CH2:19]([CH:21]([CH2:24][CH2:25][CH2:26][CH3:27])[CH2:22]Br)[CH3:20]>CN(C)C=O>[CH2:19]([CH:21]([CH2:24][CH2:25][CH2:26][CH3:27])[CH2:22][O:12][C:7]1[C:6]2[C:11](=[C:2]([O:16][CH2:13][CH:2]([CH2:11][CH3:10])[CH2:3][CH2:4][CH2:5][CH3:6])[CH:3]=[CH:4][CH:5]=2)[CH:10]=[CH:9][CH:8]=1)[CH3:20]

참가 물질

5

반응물 3

HCID 67491,5-DihydroxynaphthaleneHCID 11430Potassium CarbonateHCID 868042-Ethylhexyl bromide

생성물 1

HCID 709804481,5-Bis-(2-ethylhexyloxy)naphthalene수율 133.3%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

5.0 g of 1,5-dihydroxynaphthalene (31.2 mmol) and 43.1 g of potassium carbonate (311 mmol) were dissolved in 50 mL of dimethylformamide (DMF). 18.0 g of 2-ethylhexyl bromide (93.2 mmol) was added thereto and stirred at 1000 for 24 hours. After the mixture was quenched with water, extracted with ethylacetate, and sequentially washed with water and salt water, excess water was removed using magnesium sulfate, followed by column chromatography, thereby obtaining 8.0 g of the title compound (66.6%).

후처리

  1. customAfter the mixture was quenched with water
  2. extractionextracted with ethylacetate
  3. washsequentially washed with water and salt water, excess water
  4. customwas removed

출처 및 근거

ORD 기록
ord-ee8e50b784ce4b5c8f95386e4ee31b1d
출처 데이터셋
uspto-grants-2016_01
특허 번호
US09236573B2

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