Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 2-Chloro-4-(4,4-difluoropiperidin-1-yl)-6-((2,2,2-trifluoroethoxy)methyl)pyrimidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | 4,4-Difluoropiperidine | HCID 2758352 | — |
| 반응물 | Sodium Methoxide | HCID 10942334 | — |
| 반응물 | 2,4-Dichloro-6-((2,2,2-trifluoroethoxy)methyl)pyrimidine | HCID 117820912 | — |
| 용매 | Methanol | HCID 887 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | 2-Chloro-4-(4,4-difluoropiperidin-1-yl)-6-((2,2,2-trifluoroethoxy)methyl)pyrimidine | HCID 117821130 | — |
반응 조건
| 온도 | 0 °C |
|---|
반응 단계
To an ice-cold solution of 2,4-dichloro-6-((2,2,2-trifluoroethoxy)methyl)pyrimidine (0.120 g, 0.46 mmol) in acetonitrile (2 mL) was a solution of 4,4-difluoropiperidine (0.217 g, 1.38 mmol) and sodium methoxide (30 wt % in methanol, 0.188 mL, 1.01 mmol) in MeOH (2 mL) added. The reaction was stirred at 0° C. for 2 hours. Water and DMF was added and the residue was purified by preparative HPLC to give the title compound as a dry film (0.110 g, 69%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09439904B2 |
| 출처 데이터셋 | uspto-grants-2016_09 |
| ORD ID | ord-379d10dffd7146a1a029057eb2a721b8 |
| 출처 메모 | uspto-grants-2016_09 |