Ethoxalyl chloride → Ethyl 3,5-dibromo-alpha-oxo-2-thiopheneacetate

참여 물질

반응 단계

Aluminium chloride (0.26 g, 1.98 mmol) was added to a solution of 2,4-dibromothiophene (0.30 g, 1.24 mmol) and ethyl chlorooxoacetate (0.19 g, 1.36 mmol) in dichloromethane (10 mL) previously cooled with an ice bath. The reaction mixture was stirred at room temperature 45 minutes, poured into ice water and extracted with dichloromethane (2×20 mL). The organic layer was dried over sodium sulfate, filtered and concentrated in vacuo to provide the desired keto-ester (10a) (0.42 g, 1.24 mmol, 100%) as a yellow oil.

출처 및 근거