{3-Bromothieno[2,3-b]pyridin-2-yl}methanol → 3-Bromothieno[2,3-b]pyridine-2-carbaldehyde

HRID 591006노트

반응식

HRID 591006 반응식
[Br:1][C:2]1[C:10]2[C:5](=[N:6][CH:7]=[CH:8][CH:9]=2)[S:4][C:3]=1[CH2:11][OH:12]>ClCCl.[O-2].[Mn+2]>[Br:1][C:2]1[C:10]2[C:5](=[N:6][CH:7]=[CH:8][CH:9]=2)[S:4][C:3]=1[CH:11]=[O:12]

참가 물질

4

반응물 1

HCID 70855402{3-Bromothieno[2,3-b]pyridin-2-yl}methanol

생성물 1

HCID 823872043-Bromothieno[2,3-b]pyridine-2-carbaldehyde

시약·촉매·용매 2

HCID 160959Manganese oxide촉매HCID 6344Dichloromethane용매

실험 절차

A mixture of {3-bromothieno[2,3-b]pyridin-2-yl}methanol (14c) (394 mg, 1.61 mmol) and manganese (II) oxide (1.4 g, 16.1 mmol) in dichloromethane (10 mL) was stirred for 20 hours, filtrated and evaporated to dryness to give the desired aldehyde (14d) without further purification (270 mg, 1.12 mmol, 70%).

후처리

  1. filtrationfiltrated
  2. customevaporated to dryness

출처 및 근거

ORD 기록
ord-191ed37298734886a2d09e97eaf0f626
출처 데이터셋
uspto-grants-2016_01
특허 번호
US09238026B2

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