3-Oxetanamine → 2-Chloro-N-(oxetan-3-yl)-6-((2,2,2-trifluoroethoxy)methyl)pyrimidin-4-amine

HRID 59106

반응식

HRID 59106 반응식
[O:1]1[CH2:4][CH:3]([NH2:5])[CH2:2]1.[Cl:6][C:7]1[N:12]=[C:11](Cl)[CH:10]=[C:9]([CH2:14][O:15][CH2:16][C:17]([F:20])([F:19])[F:18])[N:8]=1>CO.C(#N)C>[Cl:6][C:7]1[N:12]=[C:11]([NH:5][CH:3]2[CH2:4][O:1][CH2:2]2)[CH:10]=[C:9]([CH2:14][O:15][CH2:16][C:17]([F:20])([F:18])[F:19])[N:8]=1

참가 물질

5

반응물 2

HCID 98339233-OxetanamineHCID 1178209122,4-Dichloro-6-((2,2,2-trifluoroethoxy)methyl)pyrimidine

생성물 1

HCID 1178211132-Chloro-N-(oxetan-3-yl)-6-((2,2,2-trifluoroethoxy)methyl)pyrimidin-4-amine수율 55.7%

시약·촉매·용매 2

HCID 887Methanol용매HCID 6342Acetonitrile용매

실험 절차

A solution of oxetan-3-amine (77 mg, 1.06 mmol) in MeOH (2 mL) was added dropwise to an ice-cold solution of 2,4-dichloro-6-((2,2,2-trifluoroethoxy)methyl)pyrimidine (92 mg, 0.35 mmol) in acetonitrile (2 mL). The mixture stirred at rt overnight. The mixture was separated by preparative chromatography to give the title compound (58 mg, 55%).

후처리

  1. customThe mixture was separated by preparative chromatography

출처 및 근거

ORD 기록
ord-11c807dd802d43cfb2ff384df1e3eab1
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09439904B2

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