4-Aminophenylsulphur pentafluoride → 2-isopropyl-5-methyl-N-[4-(pentafluoro-$l^{6}-sulfanyl)phenyl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine

HRID 591245노트

반응식

HRID 591245 반응식
Cl[C:2]1[N:7]2[N:8]=[C:9]([CH:11]([CH3:13])[CH3:12])[N:10]=[C:6]2[N:5]=[C:4]([CH3:14])[CH:3]=1.[NH2:15][C:16]1[CH:21]=[CH:20][C:19]([S:22]([F:27])([F:26])([F:25])([F:24])[F:23])=[CH:18][CH:17]=1>C(O)C>[CH3:14][C:4]1[CH:3]=[C:2]([NH:15][C:16]2[CH:21]=[CH:20][C:19]([S:22]([F:27])([F:23])([F:24])([F:25])[F:26])=[CH:18][CH:17]=2)[N:7]2[N:8]=[C:9]([CH:11]([CH3:13])[CH3:12])[N:10]=[C:6]2[N:5]=1

참가 물질

4

반응물 2

HCID 27791904-Aminophenylsulphur pentafluorideHCID 533918637-Chloro-5-methyl-2-(1-methylethyl)[1,2,4]triazolo[1,5-a]pyrimidine

생성물 1

HCID 513475402-isopropyl-5-methyl-N-[4-(pentafluoro-$l^{6}-sulfanyl)phenyl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a suspension of Intermediate 18 (0.042 g, 0.199 mmol) in ethanol (5 mL), 4-aminophenylsulfur pentafluoride (MANCHESTER, 0.044 g, 0.199 mmol) was added and the mixture was stirred at room temperature overnight. Solvent was removed in vacuo and the crude mixture was purified by flash chromatography (Si, eluting with Hexane/EtOAc mixtures from 75:25 to 25:75%) to yield the title compound as a white solid.

후처리

  1. additionwas added
  2. customSolvent was removed in vacuo
  3. customthe crude mixture was purified by flash chromatography (Si, eluting with Hexane/EtOAc mixtures from 75:25 to 25:75%)

출처 및 근거

ORD 기록
ord-3f393256bf0b40469a209d91f8179e31
출처 데이터셋
uspto-grants-2016_01
특허 번호
US09238653B2

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