Di-tert-butyl (4S)-4-{4-[3-(benzyloxy)propyl]benzyl}-N-(tert-butoxycarbonyl)-L-glutamate → Di-tert-butyl (4S)-N-(tert-butoxycarbonyl)-4-[4-(3-hydroxypropyl)benzyl]-L-glutamate

HRID 591267노트

반응식

HRID 591267 반응식
C([O:8][CH2:9][CH2:10][CH2:11][C:12]1[CH:43]=[CH:42][C:15]([CH2:16][C@H:17]([C:35]([O:37][C:38]([CH3:41])([CH3:40])[CH3:39])=[O:36])[CH2:18][C@@H:19]([C:28]([O:30][C:31]([CH3:34])([CH3:33])[CH3:32])=[O:29])[NH:20][C:21]([O:23][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:22])=[CH:14][CH:13]=1)C1C=CC=CC=1>CO.[Pd]>[C:24]([O:23][C:21]([NH:20][C@H:19]([C:28]([O:30][C:31]([CH3:34])([CH3:33])[CH3:32])=[O:29])[CH2:18][C@H:17]([CH2:16][C:15]1[CH:42]=[CH:43][C:12]([CH2:11][CH2:10][CH2:9][OH:8])=[CH:13][CH:14]=1)[C:35]([O:37][C:38]([CH3:40])([CH3:39])[CH3:41])=[O:36])=[O:22])([CH3:25])([CH3:26])[CH3:27]

참가 물질

4

반응물 1

HCID 131734509Di-tert-butyl (4S)-4-{4-[3-(benzyloxy)propyl]benzyl}-N-(tert-butoxycarbonyl)-L-glutamate

생성물 1

HCID 70957093Di-tert-butyl (4S)-N-(tert-butoxycarbonyl)-4-[4-(3-hydroxypropyl)benzyl]-L-glutamate

시약·촉매·용매 2

HCID 887Methanol용매HCID 23938Palladium용매

실험 절차

To a solution of 690 mg (1.15 mmol) di-tert-butyl (4S)-4-{4-[3-(benzyloxy)propyl]benzyl}-N-(tert-butoxycarbonyl)-L-glutamate in 17 mL of methanol, palladium (10% on charcoal) was added and the suspension was stirred overnight at room temperature under a hydrogen atmosphere. The mixture was filtered over celite, and the solvent was evaporated. The remaining material was used without purification.

후처리

  1. filtrationThe mixture was filtered over celite
  2. customthe solvent was evaporated
  3. customThe remaining material was used without purification

출처 및 근거

ORD 기록
ord-18cb67082fdf47aba5c32b399b2581a9
출처 데이터셋
uspto-grants-2016_01
특허 번호
US09238631B2

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