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Triethylamine → HCID 89767843, 화합물

HRID 591480
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인쇄 미리보기

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HRID 591480 반응식
[Cl:1][C:2]1[C:6]2[CH:7]=[CH:8][C:9]([O:11][CH2:12][C:13]3[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][C:14]=3[Cl:20])=[CH:10][C:5]=2[S:4][C:3]=1[C:21]([OH:23])=O.CC[N:26]=C=NCCCN(C)C.C(N(CC)CC)C>CN(C=O)C.C([O-])(O)=O.[Na+].O>[Cl:1][C:2]1[C:6]2[CH:7]=[CH:8][C:9]([O:11][CH2:12][C:13]3[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][C:14]=3[Cl:20])=[CH:10][C:5]=2[S:4][C:3]=1[C:21]([NH2:26])=[O:23]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

7

반응물 3

HCID 8471TriethylamineHCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 89768127HCID 89768127, 화합물

생성물 1

HCID 89767843HCID 89767843, 화합물수율 102.7%

시약·촉매·용매 3

HCID 962Water용매HCID 6228Dimethylformamide용매
HCID 516892
Sodium Bicarbonate
용매

실험 절차

To a solution of 3-chloro-6-((2,4-dichlorobenzyl)oxy)-1-benzothiophene-2-carboxylic acid (190.4 mg) in DMF (dry) (4.9 mL) were added HOBt ammonia complex (112 mg), EDCI (141 mg) and triethylamine (0.205 mL). The mixture was stirred at room temperature overnight. The mixture was diluted with saturated aqueous NaHCO3 and water. The precipitate was collected by filtration, and washed with water and hexane to give the title compound (195 mg).

후처리

  1. filtrationThe precipitate was collected by filtration
  2. washwashed with water and hexane

출처 및 근거

ORD 기록
ord-5ecfcf7d506f4c22bb65cfee9f004db5
출처 데이터셋
uspto-grants-2016_01
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US09238639B2

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