Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
tert-Butanol → Ethyl 4-methyl-2-(trifluoromethyl)thiazole-5-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | tert-Butanol | HCID 6386 | — |
| 반응물 | Ethyl 2-chloroacetoacetate | HCID 11858 | — |
| 반응물 | Trifluoroethanethioamide | HCID 4425751 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | Ethyl 4-methyl-2-(trifluoromethyl)thiazole-5-carboxylate | HCID 46835627 | — |
반응 단계
To a mixture of 2,2,2-trifluoroethanethioamide (200 mg) and t-BuOH (10 mL) was added ethyl 2-chloro-3-oxobutanoate (0.217 mL) at room temperature. The mixture was refluxed for 2 days. After cooling, EtOAc was poured into the mixture, and the mixture was washed successively with water and brine, dried over Na2SO4 and concentrated in vacuo. The residue was purified by silica gel column chromatography (NH, EtOAc/hexane) to give the title compound (133 mg).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09238639B2 |
| 출처 데이터셋 | uspto-grants-2016_01 |
| ORD ID | ord-efea65c911b44c3f9e75c2d061f7696b |
| 출처 메모 | uspto-grants-2016_01 |