Acetyl chloride → HCID 66745169, 화합물

HRID 591653노트

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HRID 591653 반응식
[CH:1]([NH:4][CH:5]1[CH2:10][CH2:9][N:8]([C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12])[CH2:7][CH2:6]1)([CH3:3])[CH3:2].CCN(CC)CC.[C:25](Cl)(=[O:27])[CH3:26]>C(Cl)Cl>[CH:1]([N:4]([CH:5]1[CH2:6][CH2:7][N:8]([C:11]([O:13][C:14]([CH3:15])([CH3:17])[CH3:16])=[O:12])[CH2:9][CH2:10]1)[C:25](=[O:27])[CH3:26])([CH3:3])[CH3:2]

참가 물질

5

반응물 3

HCID 6367Acetyl chlorideHCID 8471TriethylamineHCID 20801236tert-Butyl 4-[(propan-2-yl)amino]piperidine-1-carboxylate

생성물 1

HCID 66745169HCID 66745169, 화합물수율 59.6%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a 0° C. solution of tert-butyl 4-(isopropylamino)piperidine-1-carboxylate (1.2 g, 5.19 mmol) in CH2Cl2 (18 mL) was added Et3N (1.44 mL, 10.38 mmol) followed by acetyl chloride (0.55 mL, 7.78 mmol). The resulting solution was stirred for 2.5 hours, then concentrated in vacuo. The material was purified by flash chromatography on silica gel, eluting with 0% to 5% of EtOAc/CH2Cl2, to afford tert-butyl 4-(N-isopropylacetamido)piperidine-1-carboxylate (0.88 g, 59%).

후처리

  1. concentrationconcentrated in vacuo
  2. customThe material was purified by flash chromatography on silica gel
  3. washeluting with 0% to 5% of EtOAc/CH2Cl2

출처 및 근거

ORD 기록
ord-060ac4bd04dc4d37ab025f0b7a3d2459
출처 데이터셋
uspto-grants-2016_01
특허 번호
US09238640B2

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