Potassium Carbonate → 4-{[4-(Propan-2-yl)piperazin-1-yl]methyl}benzaldehyde

HRID 591788노트

반응식

HRID 591788 반응식
BrC[CH2:3][C:4]1[CH:11]=[CH:10][C:7]([CH:8]=[O:9])=[CH:6][CH:5]=1.C([O-])([O-])=O.[K+].[K+].[CH:18]([N:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1)([CH3:20])[CH3:19]>CN(C=O)C>[CH:18]([N:21]1[CH2:26][CH2:25][N:24]([CH2:3][C:4]2[CH:5]=[CH:6][C:7]([CH:8]=[O:9])=[CH:10][CH:11]=2)[CH2:23][CH2:22]1)([CH3:20])[CH3:19]

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 780131-IsopropylpiperazineHCID 110851354-(2-Bromoethyl)benzaldehyde

생성물 1

HCID 866620354-{[4-(Propan-2-yl)piperazin-1-yl]methyl}benzaldehyde수율 97.4%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To a mixture of 4-(bromoethyl)benzaldehyde (0.200 g, 1.0 mmol) and K2CO3 (0.277 g, 2.0 mmol) in DMF (5 mL) was added N-isopropylpiperazine (0.129 g, 1.0 mmol) and the reaction was stirred at room temperature for 5 hours, then concentrated in vacuo. The resulting mixture was diluted with H2O and extracted with EtOAc. The organics were washed with brine, dried over anhydrous Na2SO4, filtered, and concentrated in vacuo to afford 4-((4-Isopropylpiperazin-1-yl)methyl)benzaldehyde (0.240 g, 97%).

후처리

  1. concentrationconcentrated in vacuo
  2. additionThe resulting mixture was diluted with H2O
  3. extractionextracted with EtOAc
  4. washThe organics were washed with brine
  5. dry with materialdried over anhydrous Na2SO4
  6. filtrationfiltered
  7. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-a63aa1d34ef64ad8b344a3908eb1c517
출처 데이터셋
uspto-grants-2016_01
특허 번호
US09238640B2

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