Methanol → 7-fluoro-5-methoxy-2-pyridin-4-yl-3H-quinazolin-4-one

HRID 591799노트

반응식

HRID 591799 반응식
F[C:2]1[CH:11]=[C:10]([F:12])[CH:9]=[C:8]2[C:3]=1[C:4](=[O:19])[NH:5][C:6]([C:13]1[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=1)=[N:7]2.[CH3:20][O-:21].[Na+].CO.O>CN(C=O)C.C(O)(=O)C>[F:12][C:10]1[CH:9]=[C:8]2[C:3]([C:4](=[O:19])[NH:5][C:6]([C:13]3[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=3)=[N:7]2)=[C:2]([O:21][CH3:20])[CH:11]=1

참가 물질

7

반응물 4

HCID 887MethanolHCID 962WaterHCID 10942334Sodium MethoxideHCID 1363794005,7-difluoro-2-pyridin-4-yl-3H-quinazolin-4-one

생성물 1

HCID 1363480537-fluoro-5-methoxy-2-pyridin-4-yl-3H-quinazolin-4-one

시약·촉매·용매 2

HCID 176Acetic Acid용매HCID 6228Dimethylformamide용매

실험 절차

To a suspension of 5,7-difluoro-2-pyridin-4-yl-3H-quinazolin-4-one (0.20 g, 0.80 mmol) in DMF (3 mL) was added sodium methoxide in methanol (0.43 g, 8.0 mmol) and the reaction mixture was stirred at room temperature for 16 hours. Water was added, the mixture was acidified with acetic acid to pH approximately 4-5, and the precipitated solid was filtered off to obtain 7-fluoro-5-methoxy-2-pyridin-4-yl-3H-quinazolin-4-one as a yellowish solid. Yield: 0.20 g (83%).

후처리

  1. filtrationthe precipitated solid was filtered off

출처 및 근거

ORD 기록
ord-69d7f965874e4b4c8ae05f4b31332b45
출처 데이터셋
uspto-grants-2016_01
특허 번호
US09238640B2

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