N-Methylpiperidine → 4-(2-(4-Methylpiperazin-1-yl)-2-oxoethoxy)benzaldehyde

HRID 592084노트

반응식

HRID 592084 반응식
[CH:1]([C:3]1[CH:13]=[CH:12][C:6]([O:7][CH2:8][C:9]([OH:11])=O)=[CH:5][CH:4]=1)=[O:2].CN1CCCCC1.C(C1C=C(C=CC=1)OC[C:28]([N:30]1[CH2:35][CH2:34][N:33](C(OC(C)(C)C)=O)[CH2:32][CH2:31]1)=O)=O>>[CH3:28][N:30]1[CH2:35][CH2:34][N:33]([C:9](=[O:11])[CH2:8][O:7][C:6]2[CH:5]=[CH:4][C:3]([CH:1]=[O:2])=[CH:13][CH:12]=2)[CH2:32][CH2:31]1

참가 물질

4

반응물 3

HCID 12291N-MethylpiperidineHCID 89177Acetic acid, 2-(4-formylphenoxy)-HCID 89725867Tert-Butyl 4-(2-(3-formylphenoxy)acetyl)piperazine-1-carboxylate

생성물 1

HCID 283794934-(2-(4-Methylpiperazin-1-yl)-2-oxoethoxy)benzaldehyde수율 66%

실험 절차

2-(4-Formylphenoxy)acetic acid (53) was treated with 1-methylpiperidine in an analogous manner to Compound 49 to afford the desired product (66%) as a colorless oil. LCMS: 99.0% (M++1).

출처 및 근거

ORD 기록
ord-faedc26ebb2d4a61a725f1b1aaa7de48
출처 데이터셋
uspto-grants-2016_01
특허 번호
US09238656B2

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