Trifluoroacetic acid → HCID 89726233, 화합물

HRID 592088노트

반응식

HRID 592088 반응식
[CH:1]([C:3]1[CH:4]=[C:5]([CH:20]=[CH:21][CH:22]=1)[O:6][CH:7]1[CH2:12][CH2:11][N:10]([C:13](OC(C)(C)C)=[O:14])[CH2:9][CH2:8]1)=[O:2].C(O)([C:25]([F:28])([F:27])[F:26])=O>C(Cl)Cl>[F:26][C:25]([F:28])([F:27])[C:13]([N:10]1[CH2:11][CH2:12][CH:7]([O:6][C:5]2[CH:4]=[C:3]([CH:22]=[CH:21][CH:20]=2)[CH:1]=[O:2])[CH2:8][CH2:9]1)=[O:14]

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 53439173tert-Butyl 4-(3-formylphenoxy)piperidine-1-carboxylate

생성물 1

HCID 89726233HCID 89726233, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

tert-butyl 4-(3-formylphenoxy)piperidine-1-carboxylate (61) (5.55 mmol) was taken in DCM and cooled to 0° C. when TFA (5 ml) was added drop wise and then stirred at rt for 16 h when TLC confirmed completion of reaction. The reaction mixture was concentrated and used directly for the next step. White solid.

후처리

  1. additionwas added drop wise
  2. customcompletion of reaction
  3. concentrationThe reaction mixture was concentrated

출처 및 근거

ORD 기록
ord-3a4fccb6708048f1a3076f438139c3ae
출처 데이터셋
uspto-grants-2016_01
특허 번호
US09238656B2

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