Potassium Cyanide → 4-Bromo-3-(trifluoromethyl)phenylacetonitrile

HRID 592137노트

반응식

HRID 592137 반응식
CS(O[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([Br:13])=[C:9]([C:14]([F:17])([F:16])[F:15])[CH:8]=1)(=O)=O.[C-:18]#[N:19].[K+]>C(O)C.O>[Br:13][C:10]1[CH:11]=[CH:12][C:7]([CH2:6][C:18]#[N:19])=[CH:8][C:9]=1[C:14]([F:17])([F:16])[F:15]

참가 물질

5

반응물 2

HCID 9032Potassium CyanideHCID 866579514-Bromo-3-(trifluoromethyl)benzyl methanesulfonate

생성물 1

HCID 459337024-Bromo-3-(trifluoromethyl)phenylacetonitrile

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

실험 절차

To a solution of 4-bromo-3-(trifluoromethyl)benzyl methanesulfonate 46-4 (1.295 g, 3.75 mmol) in ethanol (10 mL) was added a solution of potassium cyanide (364 mg, 5.6 mmol) in water (2 mL). The mixture was refluxed for 2 hours. After the mixture was cooled down to the room temperature, all the solvents were evaporated and the residue was redissolved in dichloromethane (50 mL), washed with water and brine, dried over Na2SO4, and concentrated to dryness to give 2-(4-bromo-3-(trifluoromethyl)phenyl)acetonitrile 46-5 as dark brown oil, which was used for next step directly. MS m/z 264.1 (M+1)

후처리

  1. temperatureThe mixture was refluxed for 2 hours
  2. customwere evaporated
  3. dissolutionthe residue was redissolved in dichloromethane (50 mL)
  4. washwashed with water and brine
  5. dry with materialdried over Na2SO4
  6. concentrationconcentrated to dryness

출처 및 근거

ORD 기록
ord-68c6a1513b0243d09de6da5516d00593
출처 데이터셋
uspto-grants-2016_01
특허 번호
US09238646B2

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