참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Potassium Phosphate, Tribasic | HCID 62657 | — |
| 반응물 | 2-Fluoropyridine-4-boronic acid | HCID 2783396 | — |
| 반응물 | 2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl | HCID 11269872 | — |
| 반응물 | 2-(6-Chloro-5-methylpyridin-3-yl)acetic acid | HCID 55267357 | — |
| 촉매 | palladium(II) acetate | HCID 167845 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 용매 | (+-)-2-Butanol | HCID 6568 | — |
| 생성물 | 2-(2'-Fluoro-3-methyl-2,4'-bipyridin-5-yl)acetic acid | HCID 58447692 | — |
반응 단계
To a reaction vial was added 2-(6-chloro-5-methylpyridin-3-yl)acetic acid 74-4 (185 mg, 1 mmol), 2-fluoropyridin-4-ylboronic acid 193-1 (220 mg, 1.5 mmol), Pd(OAc)2 (12 mg, 0.05 mmol), S-Phos (41 mg, 0.1 mmol) and K3PO4 (636 mg, 3 mmol) in 1 mL 2-butanol. The reaction was heated to 100° C. and stirred for 2 hours. The reaction was cooled down to room temperature and then diluted to DMSO. The reaction mixture was filtered and the filtrate was purified by reverse-phase HPLC to give 2-(2′-fluoro-3-methyl-2,4′-bipyridin-5-yl)acetic acid 193-2 as white solid. MS m/z 247.2 (M+1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US09238646B2 |
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| 출처 데이터셋 | uspto-grants-2016_01 |
|---|
| ORD ID | ord-936fab4025584279a7269a8688b5ec03 |
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| 출처 메모 | uspto-grants-2016_01 |
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