Oxalyl chloride → 2-Chloro-6-fluorobenzoyl isocyanate

HRID 59236노트

반응식

HRID 59236 반응식
[Cl:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([F:11])[C:3]=1[C:4]([NH2:6])=[O:5].C(Cl)(=O)[C:13](Cl)=[O:14]>C(Cl)CCl>[Cl:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([F:11])[C:3]=1[C:4]([N:6]=[C:13]=[O:14])=[O:5]

참가 물질

4

반응물 2

HCID 65578Oxalyl chlorideHCID 985642-Chloro-6-fluorobenzamide

생성물 1

HCID 130517312-Chloro-6-fluorobenzoyl isocyanate수율 91,106.602%

시약·촉매·용매 1

HCID 111,2-Dichloroethane용매

실험 절차

To a solution of 2-chloro-6-fluorobenzamide (2.0 g, 0.011 mmol) in EDC (10 mL) was added oxalyl chloride (2.18 g, 0.017 mmol). The reaction mass was refluxed for 24 h. Excess of solvent was removed under vacuum to afford 2.0 g of desired product.

후처리

  1. temperatureThe reaction mass was refluxed for 24 h
  2. customExcess of solvent was removed under vacuum

출처 및 근거

ORD 기록
ord-4548ea085f674a4d899d467001b5b831
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09439890B2

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