Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Boron trifluoride → 1-(4-(Trifluoromethyl)phenyl)cyclopropanamine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Boron trifluoride | HCID 6356 | — |
| 반응물 | Benzonitrile, 4-(trifluoromethyl)- | HCID 67995 | — |
| 반응물 | HCID 178418443 | HCID 178418443 | — |
| 촉매 | Titanium isopropoxide | HCID 11026 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 생성물 | 1-(4-(Trifluoromethyl)phenyl)cyclopropanamine | HCID 53420453 | 180% |
반응 단계
The title compound was prepared according to the procedure described in Intermediate-12 by using of 4-(trifluoromethyl)benzonitrile (1.0 g, 0.58 mmol), diethyl ether (20 mL), titanium isopropoxide (2.0 g, 0.70 mmol), ethyl magnesium bromide (4.30 mL, 12.86 mmol) and boron trifluoride solution (1.5 mL) to afford 0.210 g of desired product. 1H NMR (CDCl3): δ 1.05 (s, 2H), 1.60 (s, 2H), 1.78 (s, 2H), 7.36 (d, J=7.8 Hz, 2H), 7.55 (d, J=8.1 Hz, 2H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09439890B2 |
| 출처 데이터셋 | uspto-grants-2016_09 |
| ORD ID | ord-1907ea81c3484ddbbe15735aea810ce6 |
| 출처 메모 | uspto-grants-2016_09 |