Boron trifluoride → 1-(4-(Trifluoromethyl)phenyl)cyclopropanamine

HRID 59248

반응식

HRID 59248 반응식
[F:1][C:2]([F:12])([F:11])[C:3]1[CH:10]=[CH:9][C:6]([C:7]#[N:8])=[CH:5][CH:4]=1.[CH2:13]([Mg]Br)[CH3:14].B(F)(F)F>CC(C)[O-].[Ti+4].CC(C)[O-].CC(C)[O-].CC(C)[O-].C(OCC)C>[F:1][C:2]([F:11])([F:12])[C:3]1[CH:10]=[CH:9][C:6]([C:7]2([NH2:8])[CH2:14][CH2:13]2)=[CH:5][CH:4]=1

참가 물질

6

반응물 3

HCID 6356Boron trifluorideHCID 67995Benzonitrile, 4-(trifluoromethyl)-HCID 178418443HCID 178418443, 화합물

생성물 1

HCID 534204531-(4-(Trifluoromethyl)phenyl)cyclopropanamine수율 180%

시약·촉매·용매 2

HCID 11026Titanium isopropoxide촉매HCID 3283Diethyl Ether용매

실험 절차

The title compound was prepared according to the procedure described in Intermediate-12 by using of 4-(trifluoromethyl)benzonitrile (1.0 g, 0.58 mmol), diethyl ether (20 mL), titanium isopropoxide (2.0 g, 0.70 mmol), ethyl magnesium bromide (4.30 mL, 12.86 mmol) and boron trifluoride solution (1.5 mL) to afford 0.210 g of desired product. 1H NMR (CDCl3): δ 1.05 (s, 2H), 1.60 (s, 2H), 1.78 (s, 2H), 7.36 (d, J=7.8 Hz, 2H), 7.55 (d, J=8.1 Hz, 2H).

후처리

  1. customThe title compound was prepared

출처 및 근거

ORD 기록
ord-1907ea81c3484ddbbe15735aea810ce6
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09439890B2

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