5-Chloro-2-nitropyridine → 5-(Methylthio)-2-nitropyridine

HRID 592587노트

반응식

HRID 592587 반응식
Cl[C:2]1[CH:3]=[CH:4][C:5]([N+:8]([O-:10])=[O:9])=[N:6][CH:7]=1.[CH3:11][S-:12].[Na+]>CO>[CH3:11][S:12][C:2]1[CH:3]=[CH:4][C:5]([N+:8]([O-:10])=[O:9])=[N:6][CH:7]=1

참가 물질

4

반응물 2

HCID 2598065-Chloro-2-nitropyridineHCID 4378561Sodium methanethiolate

생성물 1

HCID 220361825-(Methylthio)-2-nitropyridine수율 66%

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
20 °C

실험 절차

To a mixture of 5-chloro-2-nitropyridine (3 g, 18 mmol) in MeOH (20 mL), sodium methanethiolate (1.4 g, 20 mmol) was added at 0° C. and the mixture stirred at 20° C. for 2 hours. The resulting suspension was filtered and washed with water, and dried in vacuum to afford crude 117a as a yellow solid (2 g, 66%) without purification for next step. MS: [M+H]+ 171.

후처리

  1. additionwas added at 0° C.
  2. filtrationThe resulting suspension was filtered
  3. washwashed with water
  4. customdried in vacuum

출처 및 근거

ORD 기록
ord-2f39e386986a480a9d1112ecaf13a240
출처 데이터셋
uspto-grants-2016_01
특허 번호
US09238655B2

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