참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Methyl Salicylate | HCID 4133 | — |
| 반응물 | Propylamine | HCID 7852 | — |
| 생성물 | N-Propylsalicylamide | HCID 81966 | 84% |
반응 단계
The crude methyl 2-hydroxybenzoate was dissolved in n-propylamine (400 mL). The reaction mixture in a sealed reactor was stirred at 80° C. overnight. The reaction mixture was concentrated under reduced pressure to give the crude material that was purified by silica gel flash column chromatography to afford 120 g (84%) of 2-hydroxy-N-propylbenzamide. LCMS ESI (+) m/z 180 (M+1) detected.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US09242964B2 |
|---|
| 출처 데이터셋 | uspto-grants-2016_01 |
|---|
| ORD ID | ord-4bf1486374c54440889cb13a2d5c8637 |
|---|
| 출처 메모 | uspto-grants-2016_01 |
|---|
