Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ammonia → 4-Chloro-2-fluorobenzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ammonia | HCID 222 | — |
| 반응물 | Oxalyl chloride | HCID 65578 | — |
| 반응물 | 4-Chloro-2-fluorobenzoic acid | HCID 99152 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 4-Chloro-2-fluorobenzamide | HCID 3721849 | — |
반응 단계
The title compound was prepared according to the procedure described in step-2 of Intermediate-26 by using 4-chloro-2-fluoro benzoic acid (1.5 g), THF (25 mL), oxalyl chloride (0.5 mL) and ammonia gas to afford 1.45 g of the product. 1H NMR (300 MHz, DMSO d6): δ 7.36 (d, J=6.3 Hz, H), 7.53 (dd, J=8.7 Hz, 1H), 7.64-7.76 (m, 3H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09439890B2 |
| 출처 데이터셋 | uspto-grants-2016_09 |
| ORD ID | ord-6720709cf12d4796b5bd8bb65a28f1bf |
| 출처 메모 | uspto-grants-2016_09 |