Ammonia → 4-Iodobenzoyl isocyanate

HRID 59357

반응식

HRID 59357 반응식
[I:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](O)=[O:7])=[CH:4][CH:3]=1.[C:11](Cl)(=[O:15])C(Cl)=O.[NH3:17].C(Cl)Cl>C1COCC1>[I:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([N:17]=[C:11]=[O:15])=[O:7])=[CH:4][CH:3]=1

참가 물질

6

반응물 4

HCID 222AmmoniaHCID 6344DichloromethaneHCID 120854-Iodobenzoic acidHCID 65578Oxalyl chloride

생성물 1

HCID 149137404-Iodobenzoyl isocyanate

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

The title compound was prepared according to the procedures described in step-2 and step-3 of Intermediate-26 by using 4-iodo benzoic acid (2.0 g), oxalyl chloride (1.0 ml), ammonia gas, DCM (20 mL), THF (20 mL) to afford 1.5 g of the desired product. 1H NMR (400 MHz, DMSO d6): δ 7.17 (br s, 1H), 7.64 (d, 2H), 8.01 (s, 2H); MS (m/z): 461.14 (M+H)+.

후처리

  1. customThe title compound was prepared

출처 및 근거

ORD 기록
ord-c2114230e7974a47b00e7b91356fcf1c
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09439890B2

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