Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dimethyl Sulfoxide → 2-(4-Chlorophenyl)-5-phenylvaleronitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dimethyl Sulfoxide | HCID 679 | — |
| 반응물 | (3-Bromopropyl)benzene | HCID 12503 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | 4-Chlorobenzyl cyanide | HCID 241582 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 2-(4-Chlorophenyl)-5-phenylvaleronitrile | HCID 14147722 | — |
반응 단계
2 ml of an aqueous sodium hydroxide (1.08 g) solution was added to a 10 ml solution of dimethylsulfoxide containing 1.0 g (6.6 mmole) of 4-chlorophenylacetonitrile and 1.3 g (6.6 mmole) of 1-bromo-3-phenylpropane at room temperature. After stirring for 2 hours under the same conditions, water was added to the reaction mixture and the mixture was extracted with 10 ml of n-hexane, dried, and condensed under reduced pressure to obtain 1.78 g (yield: quantitative) of 2-(4-chlorophenyl)-5-phenylvaleronitrile.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05246958 |
| 출처 데이터셋 | uspto-grants-1993_09 |
| ORD ID | ord-fc328861075c4601a239c2cf487b943a |
| 출처 메모 | uspto-grants-1993_09 |