Trifluoroacetic acid → (S)-N-(morpholin-2-ylmethyl)acetamide

HRID 594034노트

반응식

HRID 594034 반응식
C(O)(C(F)(F)F)=O.[C:8]([NH:11][CH2:12][C@H:13]1[O:18][CH2:17][CH2:16][N:15](C(OC(C)(C)C)=O)[CH2:14]1)(=[O:10])[CH3:9]>ClCCl>[NH:15]1[CH2:16][CH2:17][O:18][C@H:13]([CH2:12][NH:11][C:8](=[O:10])[CH3:9])[CH2:14]1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 90408801(R)-tert-butyl 2-(acetamidomethyl)morpholine-4-carboxylate

생성물 1

HCID 90409089(S)-N-(morpholin-2-ylmethyl)acetamide

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a 4:1 solution of dichloromethane and TFA (0.1 M) was added (R)-tert-butyl 2-(acetamidomethyl)morpholine-4-carboxylate. After 1 h the solution was then concentrated in vacuo to give crude (S)—N-(morpholin-2-ylmethyl)acetamide which was used in the next step without further purification. LCMS (m/z) (M+H)=159.0, Rt=0.11 min.

후처리

  1. concentrationAfter 1 h the solution was then concentrated in vacuo

출처 및 근거

ORD 기록
ord-db2870fc1fef4666b9c144c5d552328c
출처 데이터셋
uspto-grants-2016_01
특허 번호
US09242969B2

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