반응식
[Cl:1][C:2]1C=C(Cl)[N:5]=[C:4](N2CCOCC2)[N:3]=1.[NH:15]1[CH2:20][CH2:19]S(=O)(=O)[CH2:17][CH2:16]1.[CH3:23][CH2:24][OH:25].C1COCC1>>[Cl:1][C:2]1[N:3]=[CH:4][N:5]=[C:16]([N:15]2[CH2:23][CH2:24][O:25][CH2:19][CH2:20]2)[CH:17]=1참가 물질
4
반응 조건
- 온도
- 100 °C
실험 절차
To a solution of 4-(4,6-dichloropyrimidin-2-yl)morpholine (1.0 equiv.) in EtOH:THF (1:1, 0.25 M) was added thiomorpholine 1,1-dioxide (1.0 equiv.) in one portion. The resulting mixture was heated to 100° C. for 42 h. The resulting mixture was then cooled to RT and concentrated in vacuo to yield an off white solid in The reaction mixture was then concentrated in vacuo and dried under high vacuum over 20 h to yield 4-(6-chloropyrimidin-4-yl)morpholine as a white solid in 97% yield. LCMS (m/z) (M+H)=333.0/334.9, Rt=0.68 min.
후처리
- temperatureThe resulting mixture was then cooled to RT
- concentrationconcentrated in vacuo
- customto yield an off white solid in The reaction mixture
- concentrationwas then concentrated in vacuo
- customdried under high vacuum over 20 h
출처 및 근거
- ORD 기록
- ord-8165ba03c8f2474a8cbd2fc4e09fe009
- 출처 데이터셋
- uspto-grants-2016_01
- 특허 번호
- US09242969B2
연결된 노트
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